Jian Zhang Selected Research

Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)

12/2020	N-myc downstream-regulated gene 2 promotes the protein stability of estrogen receptor beta via inhibition of ubiquitin-protein ligase E3A to suppress colorectal cancer.
1/2020	Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia.
7/2019	Modulation of B cell activation threshold mediated by BCR/CD40 costimulation by targeting Cbl-b for ubiquitination.
1/2019	Cullin5 deficiency promotes small-cell lung cancer metastasis by stabilizing integrin β1.
1/2019	Hypermethylation of SHISA3 Promotes Nasopharyngeal Carcinoma Metastasis by Reducing SGSM1 Stability.
1/2019	Regulation of immune responses by E3 ubiquitin ligase Cbl-b.
10/2018	FBW7 loss promotes epithelial-to-mesenchymal transition in non-small cell lung cancer through the stabilization of Snail protein.
3/2018	Small Molecular Weight Soybean Protein-Derived Peptides Nutriment Attenuates Rat Burn Injury-Induced Muscle Atrophy by Modulation of Ubiquitin-Proteasome System and Autophagy Signaling Pathway.
2/2014	E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation.
2/2014	RNF20 promotes the polyubiquitination and proteasome-dependent degradation of AP-2α protein.

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Jian Zhang Research Topics

Disease

956	Neoplasms (Cancer) 12/2022 - 07/2002
173	Breast Neoplasms (Breast Cancer) 08/2022 - 02/2002
145	Inflammation (Inflammations) 05/2022 - 11/2004
137	Neoplasm Metastasis (Metastasis) 04/2022 - 04/2002
135	Infections 06/2022 - 11/2002
96	Hepatocellular Carcinoma (Hepatoma) 01/2022 - 12/2003
93	Carcinogenesis 01/2022 - 07/2003
89	Lung Neoplasms (Lung Cancer) 11/2022 - 12/2004
74	Heart Failure 10/2022 - 06/2002
73	Necrosis 06/2022 - 12/2004
67	Fibrosis (Cirrhosis) 10/2022 - 08/2003
64	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2022 - 12/2002
59	Myocardial Infarction 03/2022 - 05/2005
58	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 10/2003
56	Stomach Neoplasms (Stomach Cancer) 03/2022 - 09/2006
56	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 04/2002
54	Hypoxia (Hypoxemia) 10/2022 - 10/2007
52	Carcinoma (Carcinomatosis) 05/2022 - 10/2003
45	Pain (Aches) 01/2022 - 04/2005
42	Glioma (Gliomas) 01/2022 - 04/2008
40	Body Weight (Weight, Body) 12/2022 - 06/2003
37	Alzheimer Disease (Alzheimer's Disease) 05/2022 - 09/2003
37	Nasopharyngeal Carcinoma 01/2022 - 04/2011
37	Ischemia 01/2022 - 01/2006
36	Infarction (Infarctions) 03/2022 - 05/2005
36	Wounds and Injuries (Trauma) 09/2021 - 08/2003
35	Cardiovascular Diseases (Cardiovascular Disease) 03/2022 - 07/2006
32	Stroke (Strokes) 11/2022 - 12/2004
32	Reperfusion Injury 10/2022 - 05/2007
31	Adenocarcinoma of Lung 03/2022 - 04/2008
28	Hemorrhage 04/2022 - 11/2003
28	Asthma (Bronchial Asthma) 01/2022 - 04/2005
27	Glioblastoma (Glioblastoma Multiforme) 09/2022 - 08/2008
27	Leukemia 07/2021 - 06/2005
25	Triple Negative Breast Neoplasms 12/2022 - 02/2014
25	Thrombosis (Thrombus) 01/2021 - 04/2005
24	Disease Progression 12/2022 - 11/2008
24	Colonic Neoplasms (Colon Cancer) 07/2022 - 02/2005
24	Adenocarcinoma 03/2022 - 02/2005
24	Pancreatic Neoplasms (Pancreatic Cancer) 01/2022 - 09/2008
23	Obesity 01/2022 - 02/2004
22	Hypertension (High Blood Pressure) 10/2022 - 03/2007
22	Virus Diseases (Viral Diseases) 07/2022 - 07/2005
22	Osteosarcoma (Osteogenic Sarcoma) 01/2022 - 10/2003
22	Type 2 Diabetes Mellitus (MODY) 01/2022 - 01/2007
21	Acute Lung Injury 10/2020 - 12/2002

Drug/Important Bio-Agent (IBA)

323	Proteins (Proteins, Gene)FDA Link 12/2022 - 07/2002
169	Pharmaceutical PreparationsIBA 12/2022 - 12/2002
160	Biomarkers (Surrogate Marker)IBA 07/2022 - 07/2005
128	MicroRNAs (MicroRNA)IBA 07/2022 - 06/2010
116	Messenger RNA (mRNA)IBA 06/2022 - 08/2002
107	CytokinesIBA 05/2022 - 01/2003
94	Biological ProductsIBA 12/2022 - 07/2008
66	EnzymesIBA 08/2022 - 07/2002
64	DNA (Deoxyribonucleic Acid)IBA 09/2022 - 08/2002
59	Long Noncoding RNAIBA 10/2022 - 08/2014
54	AntigensIBA 11/2022 - 02/2002
51	Peptides (Polypeptides)IBA 11/2022 - 09/2003
49	RNA (Ribonucleic Acid)IBA 11/2022 - 10/2008
48	Glucose (Dextrose)FDA LinkGeneric 08/2022 - 03/2004
48	Small Interfering RNA (siRNA)IBA 03/2022 - 06/2006
47	LigandsIBA 03/2022 - 01/2003
45	Therapeutic UsesIBA 10/2022 - 03/2004
44	Interleukin-6 (Interleukin 6)IBA 02/2022 - 02/2006
43	Transcription Factors (Transcription Factor)IBA 11/2021 - 06/2007
41	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2022 - 11/2003
40	Cisplatin (Platino)FDA LinkGeneric 12/2022 - 12/2002
39	Immune Checkpoint InhibitorsIBA 07/2022 - 01/2018
34	Doxorubicin (Adriamycin)FDA LinkGeneric 04/2022 - 08/2011
32	CateninsIBA 01/2022 - 02/2012
32	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 02/2004
31	LipidsIBA 04/2022 - 02/2004
31	Hormones (Hormone)IBA 01/2022 - 05/2003
31	CollagenIBA 01/2022 - 01/2003
30	Phosphotransferases (Kinase)IBA 01/2022 - 07/2010
28	LipopolysaccharidesIBA 04/2022 - 06/2003
27	Interleukin-10 (Interleukin 10)IBA 01/2022 - 01/2003
25	Oxygen (Dioxygen)IBA 01/2022 - 05/2006
25	ErbB Receptors (EGF Receptor)IBA 08/2021 - 05/2008
24	Circular RNAIBA 01/2022 - 01/2019
24	Insulin (Novolin)FDA Link 01/2022 - 09/2003
23	pro-brain natriuretic peptide (1-76)IBA 10/2022 - 05/2006
23	Anti-Bacterial Agents (Antibiotics)IBA 10/2022 - 02/2004
23	VaccinesIBA 01/2022 - 03/2007
22	ChemokinesIBA 05/2022 - 06/2007
22	Indicators and Reagents (Reagents)IBA 01/2022 - 01/2010
22	Antiviral Agents (Antivirals)IBA 01/2022 - 07/2011
22	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 12/2009
21	AntioxidantsIBA 04/2022 - 11/2004
20	Gemcitabine FDA Link 12/2022 - 06/2012
20	Monoclonal AntibodiesIBA 07/2022 - 10/2005
20	Matrix Metalloproteinases (MMPs)IBA 04/2022 - 02/2007

Therapy/Procedure

377	Therapeutics 12/2022 - 10/2003
151	Drug Therapy (Chemotherapy) 09/2022 - 04/2002
85	Immunotherapy 07/2022 - 04/2004
66	Radiotherapy 09/2022 - 12/2008
42	Transplantation 06/2022 - 10/2003
26	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/2022 - 06/2007
24	Stents 08/2021 - 04/2005
22	Liver Transplantation 02/2022 - 08/2007